We use cookies to make your experience better. By continuing to browse our site you are agreeing to our use of cookies. Learn more.
The Dynamics of Tumor Microenvironment and Therapeutic Targets by Shyamasree Ghosh (Hardback)
£110.00
Available
Product Ref. (e.g. ISBN, SKU)
9781032520490
Published:
25 Nov 2025
Format:
Hardback
Number of pages:
144 pages
Dimensions:
234mm
Weight:
0.453kgs
Author:
The tumor microenvironment (TME) plays a significant role in influencing tumor aggressiveness and therapeutic outcomes, presenting both challenges and opportunities in oncology. This book provides a detailed overview of the complex nature of the TME, highlighting its dynamic cellular and molecular components.
The tumor microenvironment (TME) plays a significant role in influencing tumor aggressiveness and therapeutic outcomes, presenting both challenges and opportunities in oncology. The Dynamics of the Tumor Microenvironment and Therapeutic Targets provides a detailed overview of the complex nature of the TME, highlighting its dynamic cellular and molecular components. Each chapter systematically examines a specific element of the TME, outlining its role in tumor initiation, progression, dormancy, and suppression. The book discusses the use of molecular inhibitors that disrupt tumor-promoting interactions within the TME. Additionally, it covers immune therapies designed to reprogram immune cells in the TME to enhance the effectiveness and durability of cancer treatments. The volume also addresses recent advancements in therapeutic strategies targeting the TME, including the incorporation of contemporary computational methods. Notably, the application of artificial intelligence (AI) and machine learning (ML) to TME analysis is explored, showcasing their utility in biomarker discovery and the development of precision oncology tools.Key Features: Comprehensive coverage of the cellular and non-cellular components of the TME, with an emphasis on their phenotypic and functional heterogeneity. Detailed discussion of both targetable and non-targetable elements of the TME and their relevance in therapeutic development. A dedicated chapter on AI/ML-based methodologies for TME profiling, reflecting the emerging role of computational biology in oncology research. Critical descriptions of clinical trials targeting various aspects of the TME, alongside a synthesis of relevant translational and preclinical studies. This volume serves as a valuable resource for graduate students, early-career researchers, and established investigators in cancer biology, tumor immunology, and translational oncology. It provides foundational knowledge as well as insights into emerging therapeutic paradigms centered on the TME.
About the Author: Shyamasree Ghosh, MSc, PhD, PGDHE, PGDBI has been working in the capacity of Scientific Officer at the School of Biological Sciences (SBS), National Institute of Science Education and Research (NISER), Bhubaneswar, Orissa, India, since 2009, an OCC of HBNI, Mumbai. She graduated from the prestigious Presidency College Kolkata, under Calcutta University in 1998 with Honours in Zoology, with Chemistry and Physiology as additional subjects, and was awarded the prestigious National Scholarship from the Government of India in the same year. She completed her post-graduation in Biotechnology from Calcutta University, ranking second in the University in 2000.She completed her PhD from the Indian Institute of Chemical Biology (IICB), CSIR, Kolkata, after qualifying for the National Eligibility Test conducted by the Ministry of HRD, Government of India. Her PhD work in 2005 in the field of Childhood Acute Lymphoblastic Leukemia (ALL) was published in various national and international journals of repute. Later, she worked in the field of stem cells and nanotechnology during her post-doctoral research as a Stem Cell Scientist at Manipal Health Systems, Bangalore, and Indian Association for the Cultivation of Sciences (IACS), Kolkata. She served as the Head of the Biotechnology Department in a post-graduate college affiliated with Bangalore University until 2009.She has authored and edited 16 books, both as a single author and jointly with other co-authors. Her publications have been widely cited globally, and she has received several awards in India for her academic endeavours.Sanjima Pal, MSc, PhD, is currently working as a Research Associate (Staff Scientist) at the Research Institute of the McGill University Health Centre (RI-MUHC) in Canada. She leads a project focused on developing a patient-specific, tumor microenvironment (TME)-inclusive organ-on-chip platform to predict individualized chemosensitivity. Additionally, she is investigating altered lipid metabolism as a driver of chemoresistance and a potential therapeutic target in gastroesophageal cancer.She earned her doctoral degree in immune-chemical biology in 2017 from the School of Biological Sciences (SBS) at the National Institute of Science Education and Research (NISER), Bhubaneswar, Odisha, India. From 2016 to 2017, she worked as a Research Associate at the Crystallography and Molecular Biology Division of the Saha Institute of Nuclear Physics, Kolkata.She completed a postdoctoral research training in the Department of Radiation Oncology at the University of Michigan, Ann Arbor (2017-2020), where she contributed to a drug discovery project focused on developing a novel class of small molecules designed to degrade EGFR by disrupting its dimerization. During her second postdoctoral fellowship at McGill University, she established a microfluidic organ-on-chip platform capable of simulating clinical conditions for modeling esophageal adenocarcinoma.She is currently a member of a clinical trial team, contributing to the analysis of immune landscapes in patients with gastroesophageal adenocarcinoma undergoing perioperative chemo-immunotherapy. Her work has been widely cited, and she has presented her research at numerous national and international conferences. She has received several awards and fellowships in recognition of her academic achievements.
| Number of pages | 144 |
|---|
We will despatch your order as quickly as we can. If, for whatever reason, a product is out of stock we will contact you to discuss the likely delivery time or an alternative product.
| First Item | 2 Items & Over | |
|---|---|---|
| UK | £3.75 | £5.00 |
| EU | £15.00 | £30.00 |
| USA & Canada | £30.00 | £50.00 |
| Rest of the World | £45.00 | £60.00 |
| Collect in Store | free | free |
Additional Delivery Information (and some really important bits):
UK Delivery
Orders for delivery in the UK are normally despatched by Royal Mail, using the RM 48 Tracked Service with most orders delivered to you within a few days of placing your order with us. For larger parcels, Courier and Signed For delivery services may be used. Signed Books are shipped in our specially made book mailing cartons, with the books themselves wrapped in paper to protect them. Sometimes we may ship your order in several parts, particularly if you have 'Pre-Order' titles in your order or titles which are held in stock with our publishing partners.
The Really Important Bit: Because we use tracked, courier and signed for delivery services, please use an address at which your parcel can be received during the normal working day, for example, you may want to have your order delivered to your work address if you're not at home during the day.
First Item @ £3.75 (sometimes a shipping supplement may be added for particularly heavy books or specific postcodes*)
2 Items & over @ £5.00 in total
Another Really Important Bit: There are a number of Postcodes in the UK for which we will need to charge a shipping supplement, this will be calculated once we know the size and weight of the shipment. For these orders we will contact customers to agree a suitable and economic method of shipping. There may also be additional time required for delivery to some areas of the United Kingdom. Where possible, we will ship book orders (under 2kg) by Royal Mail to all UK postcodes. Large multiple book orders and books over 2kg are often shipped via APC Overnight or similar, regardless of Postcode.
Overseas Delivery
Shipments to EU countries:
First Item @ £15.00 (sometimes a shipping supplement will be added for particularly heavy books)
2 Items & over @ £30.00 in total
A really, really important Brexit bit: From 1st January 2021 shipments to EU addresses may incur additional costs which could be requested by Fed Ex at the time of delivery. These costs may vary from country to country and are not within our control and will be in addition to the costs paid to us for your delivery. If in any doubt, please check with your local Fed Ex office what, if any, additional costs will be applicable to your order - https://www.fedex.com
From 1st July 2021, VAT will be applicable to those EU countries where VAT is applied to books - this additional charge will be collected by Fed Ex (or the Royal Mail) at the time of delivery.
Shipments to the USA & Canada:
First Item @ £30.00
2 Items & over @ £50.00 in total
A really, really important USA Tarriff bit: From 29th August 2025 shipments to the USA are likely to incur additional duties, taxes and/or tarriffs which will be requested by the courier at the time of delivery. These costs may vary from state to state and are not within our control. These local duties, taxes and/or tarriffs will be in addition to the costs paid to us for your delivery. If you are in any doubt, please check with your local Tax Official or Fed Ex office what, if any, additional costs will be applicable to your order. The primary HTS (Harmonized Tariff Schedule) Code for a hardback book is 4901.99.0070 - https://www.fedex.com
Shipments to the Rest of the World:
First Item @ £45.00
2 Items & over @ £60.00 in total
All overseas orders are shipped using a 'signed for' courier service - please provide an address at which your parcel can be signed for on receipt. We use the same packaging materials for our overseas deliveries as we do those in the UK. In some cases, particularly large and heavy books, or books being shipped to remote areas, may incur an additional shipping charge - if this is the case with your order, we'll notify you as quickly as possible of these charges and to arrange the additional payment. You can of course cancel your order with an immediate refund should you not wish to accept these additional costs. Shipments to overseas territories may incur additional Duty & Tax costs which could be requested by Fed Ex at the time of delivery. These costs may vary from country to country and are not within our control and will be in addition to the costs paid to us for your delivery. If in any doubt, please check with your local Fed Ex office what, if any, additional Tax & Duty costs will be applicable to your order - https://www.fedex.com
Collect in Person at Coles Books
We're open Monday - Saturday, 9:00am - 5:30pm. If you're collecting your order, please wait until you get the text, phone call or email from us, just to be on the safe side and to ensure we have your order ready for you on arrival (we'll use the contact information provided during checkout). Not everything on our website is available for immediate collection, please do wait for the text, call or email - if time is of the essence, we'd suggest you call us on 01869 320779 and check availability prior to placing your order. You can pick up your order from the till, please bring a copy of your email receipt (electronic or printed is fine).
Coming by Car
If you're coming to Coles by car, why not take advantage of the 2 hours free parking at Sainsbury's Pioneer Square - just follow the signs for Pioneer Square as you drive into Bicester and park in the multi-storey car park above the supermarket. Come down the travelators, exit Sainsbury's, turn right and follow the pedestrianised walkway to Crown Walk and turn right - and Coles will be right in front of you. You don't need to shop in Sainsbury's to get the free parking!
Where to Find Us
Coles Books
22 Crown Walk
Pioneer Square
Bicester, Oxfordshire
OX26 6HY, United Kingdom
It was the most impressive packaging that I have EVER SEEN!!! The books were in perfect condition!!!!!
Super fast delivery and well packaged. Quality item and service!